abstract：:Although microRNAs (miRNAs) play an important role in esophageal squamous cell carcinoma (ESCC), their roles in radiotherapy response remain unexplored. Our study aims to investigate whether plasma miRNAs can be used as predictors of radiotherapy outcome in ESCC patients. We selected nine miRNAs, which were reported t...

journal_title：American journal of translational research

authors： Yu Q,Li B,Li P,Shi Z,Vaughn A,Zhu L,Fu S

更新日期：2015-10-15 00:00:00

abstract：:Tissue adhesion is a common postsurgical phenomenon among the human population. This complication also occurs in murine transplant models. In this study, we investigated the impact of adhesion on murine cervical heterotopic heart transplantation by using sodium hyaluronate (SH) as an anti-adhesive agent. Our study rev...

journal_title：American journal of translational research

authors： Yang J,Chen Q,Liu F,Fu Z,Wang Q

更新日期：2015-09-15 00:00:00

abstract：:Cyclooxygenase-2 expression by malignant tumors, including colonic adenocarcinoma, is associated with increased tumor aggression and poor prognosis. Nuclear factor kappa B is a key regulator of cyclooxygenase-2 and is regulated by two pathways, the 'canonical' and the 'alternative' pathway. The alternative pathway is ...

journal_title：American journal of translational research

authors： Shi G,Li D,Fu J,Sun Y,Li Y,Qu R,Jin X,Li D

更新日期：2015-09-15 00:00:00

abstract：:MicroRNAs (miRNAs) are small, non-coding RNAs which can function as oncogenes or tumor suppressor genes in human cancers. In the present study, we demonstrated that the expression ofmiR-133a was dramatically decreased in examined esophageal squamous cell carcinoma (ESCC) cell lines and clinical ESCC tissue samples. Ad...

journal_title：American journal of translational research

authors： Li S,Qin X,Li Y,Zhang X,Niu R,Zhang H,Cui A,An W,Wang X

更新日期：2015-08-15 00:00:00

abstract：:The house dust mite (HDM), Dermatophagoidesfarinae (D. farina), is one of the most important indoor allergen sources and a major elicitor of allergic asthma; itscharacterization is important in the diagnosis and immunotherapy of mite allergen-relevant diseases. This study aims to characterize a novel allergen, the D. ...

journal_title：American journal of translational research

authors： Lin J,Li M,Liu Y,Jiang C,Wu Y,Wang Y,Gao A,Liu Z,Yang P,Liu X

更新日期：2015-07-15 00:00:00

abstract：BACKGROUND:The interaction between stromal cell-derived factor 1 (SDF-1) and its receptor CXC chemokine receptor 4 (CXCR4) plays an important role in mesenchymal stem cells (MSCs) migration and engraftment. Statins can increase the survival of MSCs. However, whether statins could enhance MSCs migration and engraftment ...

journal_title：American journal of translational research

authors： Li N,Yang YJ,Qian HY,Li Q,Zhang Q,Li XD,Dong QT,Xu H,Song L,Zhang H

更新日期：2015-06-15 00:00:00

abstract：:The high-grade glioma (HGG) remains as the greatest challenge for cancer management worldwide. Identification of novel therapeutics and diagnostic method is in urgent need. The V-set and immunoglobulin domain-containing protein 4 (VSIG4) is a complement receptor for C3b/iC3b and inhibits cytotoxic T lymphocytes activa...

journal_title：American journal of translational research

authors： Xu T,Jiang Y,Yan Y,Wang H,Lu C,Xu H,Li W,Fu D,Lu Y,Chen J

更新日期：2015-06-15 00:00:00

abstract：BACKGROUND:Ulcerative colitis (UC) can be viewed as an autoimmune disease. Bone marrow-derived mesenchymal stem cells (MSCs) with its regenerative, cellular multi-lineage and immunomodulatory abilities can influence the repair of damaged tissues in UC. This study investigated the effects of MSCs transplantation on the ...

journal_title：American journal of translational research

authors： Sun T,Gao GZ,Li RF,Li X,Li DW,Wu SS,Yeo AE,Jin B

更新日期：2015-05-15 00:00:00

abstract：:Osteopontin (OPN), a malignancy-associated secreted phosphoprotein, is a prognostic plasma biomarker for survival in metastatic breast cancer patients. We evaluated the role of OPN in Locally Advanced Breast Cancer (LABC) patients in predicting response to neoadjuvant chemotherapy and association with survival. Fifty-...

journal_title：American journal of translational research

authors： Anborgh PH,Caria LB,Chambers AF,Tuck AB,Stitt LW,Brackstone M

更新日期：2015-04-15 00:00:00

abstract：BACKGROUND:To investigated the peripheral stromal cell conditioned medium (CM) -stimulated c-kit-JAK2-STAT1 pathway in prostate cancer. METHODS:CM harvested from normal prostate peripheral stromal cells was added to DU145 cells. DU145 cell viability and migration were measured by cell counting kit-8 reagent and Transw...

journal_title：American journal of translational research

authors： Guo JH,Zhou J,Zhao Y,Liu PY,Yao HJ,Da J,Zhang M,Zhou Z,Chen Q,Peng YB,Wang Z

更新日期：2015-03-15 00:00:00

abstract：:YEATS domain containing 4 (YEATS4) is usually amplified and functions as an oncogene in human glioma. However, the biological role of YEATS4 in colorectal cancer (CRC) has not yet been discussed. In this study, we investigated the expression level of YEATS4 in 85 pairs of CRC and paracancerous tissues, and knocked dow...

journal_title：American journal of translational research

authors： Tao K,Yang J,Hu Y,Deng A

更新日期：2015-03-15 00:00:00

abstract：:EZH2 is the catalytic subunit of Polycomb Repressor Complex 2 (PRC2) which catalyzes methylation of histone H3 at lysine 27 (H3K27me) and mediates gene silencing of target genes via local chromatin reorganization. Numerous evidences show that EZH2 plays a critical role in cancer initiation, progression and metastasis,...

journal_title：American journal of translational research

authors： Völkel P,Dupret B,Le Bourhis X,Angrand PO

更新日期：2015-02-15 00:00:00

abstract：:BikDD, a phosphorylation-mimic mutant of pro-apoptotic protein Bik, elicits strong apoptosis in cancer cells when introduced via an expression platform termed VP16-GAL4-WPRE integrated systemic amplifier (VISA) under the control of a cancer-specific promoter both in vitro and in vivo. C-VISA-BikDD expression plasmid e...

journal_title：American journal of translational research

authors： Sun Y,Ponz-Sarvise M,Chang SS,Chang WC,Chen CH,Hsu JL,Hung MC

更新日期：2015-02-15 00:00:00

abstract：:Enoxaparin is used postoperatively for the prevention of venous thromboembolism. In vitro studies and clinical trials have demonstrated the anticoagulant and antithrombotic efficacy of enoxaparin. In this study, we visualised thromboprophylactic and thrombolytic efficacy of enoxaparin in a laser-induced thrombus forma...

journal_title：American journal of translational research

authors： Tanaka K,Koike Y,Matsushita K,Okigami M,Toiyama Y,Kawamura M,Saigusa S,Okugawa Y,Inoue Y,Uchida K,Araki T,Mohri Y,Mizoguchi A,Kusunoki M

更新日期：2015-01-15 00:00:00

abstract：INTRODUCTION:Mesenchymal stem cells (MSCs) contribute to the engraftment of transplanted hematopoietic stem cells (HSCs). MSCs also accelerate hematological recovery by secreting SDF-1 and enabling HSCs to enter the bone marrow (BM) via the SDF-1/CXCR4 axis. HOXB4 has been shown to stimulate HSC self-renewal. In this s...

journal_title：American journal of translational research

authors： Chen T,Zhang P,Fan W,Qian F,Pei L,Xu S,Zou Z,Ni B,Zhang Y

更新日期：2014-11-22 00:00:00

abstract：:Epithelial-mesenchymal transition (EMT) was shown to enhance metastatic abilities of cancer cells, but it remains elusive in clinical samples. Moreover, EMT is rarely studied in lymph node metastases (LNM), thus limiting our understanding of its role outside of the primary tumors (PT). We collected a set of samples in...

journal_title：American journal of translational research

authors： Markiewicz A,Wełnicka-Jaśkiewicz M,Seroczyńska B,Skokowski J,Majewska H,Szade J,Żaczek AJ

更新日期：2014-11-22 00:00:00

abstract：:Observational research suggests that exercise may reduce the risk of breast cancer and improve survival. One proposed mechanism for the protective effect of aerobic exercise related to cancer risk and outcomes, but has not been examined definitively, is the immune response to aerobic exercise. Two prevailing paradigms...

journal_title：American journal of translational research

authors： Goh J,Niksirat N,Campbell KL

更新日期：2014-10-11 00:00:00

abstract：BACKGROUND:Annexin A1 was investigated as prognostic factor because of its apparent association with tumorigenesis. The aim of this study was to investigate the expression of annexin A1 in lung cancer patients, and analysed the relationship with respect to the clinico-pathological features and assessed whether annexin ...

journal_title：American journal of translational research

authors： Rong B,Zhao C,Liu H,Ming Z,Cai X,Gao W,Yang S

更新日期：2014-10-11 00:00:00

abstract：:Global microRNA (miRNA) profile may predict prostate cancer (PCa) behaviors. In this study, we examined global miRNA expression by miRNA profiling as well as specific miRNA expression levels in PCa epithelium and stroma by in situ hybridization (ISH) and correlated with various clinicopathological features. We first p...

journal_title：American journal of translational research

authors： Ren Q,Liang J,Wei J,Basturk O,Wang J,Daniels G,Gellert LL,Li Y,Shen Y,Osman I,Zhao J,Melamed J,Lee P

更新日期：2014-07-18 00:00:00

abstract：:Extracorporeal pulsed electromagnetic field (PEMF) has been shown the ability to improve regeneration in various ischemic episodes. Here, we examined whether PEMF therapy facilitate cardiac recovery in rat myocardial infarction (MI), and the cellular/molecular mechanisms underlying PEMF-related therapy was further inv...

journal_title：American journal of translational research

authors： Hao CN,Huang JJ,Shi YQ,Cheng XW,Li HY,Zhou L,Guo XG,Li RL,Lu W,Zhu YZ,Duan JL

更新日期：2014-05-15 00:00:00

abstract：:Due to practical and ethical concerns associated with human experimentation, animal models have been essential in cancer research. However, the average rate of successful translation from animal models to clinical cancer trials is less than 8%. Animal models are limited in their ability to mimic the extremely complex ...

journal_title：American journal of translational research

authors： Mak IW,Evaniew N,Ghert M

更新日期：2014-01-15 00:00:00

abstract：:Recent studies suggest that inhibiting the protein myostatin, a negative regulator of skeletal muscle mass, may improve outcomes in patients with Duchenne muscular dystrophy by enhancing muscle mass. When the dystrophin-deficient golden retriever muscular dystrophy (GRMD) dog was bred with whippets having a heterozygo...

journal_title：American journal of translational research

authors： Cotten SW,Kornegay JN,Bogan DJ,Wadosky KM,Patterson C,Willis MS

更新日期：2013-12-01 00:00:00

abstract：:Accumulation of amyloid-β (Aβ) peptides (predominantly Aβ40, 42) and their aggregation into plaques in the brain are thought to be the one of the major causes of Alzheimer's disease (AD). Originally discovered in our Chinese hamster ovary (CHO) cell line stably expressing human wild-type amyloid precursor protein (APP...

journal_title：American journal of translational research

authors： Habib A,Deng J,Hou H,Zou Q,Giunta B,Wang YJ,Obregon D,Sawmiller D,Li S,Mori T,Tan J

更新日期：2013-09-25 00:00:00

abstract：:This study examined the homing capacity of human induced pluripotent stem cell-derived endothelial cells (iPSC-ECs) and their response to chemotactic gradients of stromal derived factor-1α (SDF). We have previously shown that EC derived from murine pluripotent stem cells can home to the ischemic hindlimb of the mouse....

journal_title：American journal of translational research

authors： Huang NF,Dewi RE,Okogbaa J,Lee JC,Jalilrufaihah A,Heilshorn SC,Cooke JP

更新日期：2013-08-15 00:00:00

abstract：:THE GOAL OF THIS STUDY IS TO EMPLOY THE HALOTAG TECHNOLOGY FOR POSITRON EMISSION TOMOGRAPHY (PET), WHICH INVOLVES TWO COMPONENTS: the HaloTag protein (a modified hydrolase which covalently binds to synthetic ligands) and HaloTag ligands (HTLs). 4T1 murine breast cancer cells were stably transfected to express HaloTag ...

journal_title：American journal of translational research

authors： Hong H,Benink HA,Uyeda HT,Valdovinos HF,Zhang Y,Meisenheimer P,Barnhart TE,Fan F,Cai W

更新日期：2013-04-19 00:00:00

abstract：:Bronchopulmonary dysplasia (BPD) is one of the most common causes of mortality and morbidity in neonatal intensive care units. Persistent inflammation, with an abnormal influx of polymorphonuclear leukocytes (PMNs) followed by monocytes (MONOs), occurs early in the pathogenesis of BPD. Anti-inflammatory therapy with b...

journal_title：American journal of translational research

authors： Davidson D,Patel H,Degoy AC,Gershkovich I,Vancurova I,Miskolci V

更新日期：2013-01-01 00:00:00

abstract：:We recently reported a novel anticancer small molecule, designated FL118, which was discovered via high throughput screening (HTS), and followed by hit-lead in vitro and in vivo analysis. FL118 selectively inhibits the expression of four major cancer survival-associated gene products (survivin, Mcl-1, XIAP, and cIAP2)...

journal_title：American journal of translational research

authors： Ling X,Li F

更新日期：2013-01-01 00:00:00

abstract：:CD105 (endoglin) is an independent marker for poor prognosis in more than 10 solid tumor types. The goal of this study was to develop a CD105-specific agent for both positron emission tomography (PET) and near-infrared fluorescence (NIRF) imaging, which has potential clinical applications in the diagnosis and imaged-g...

journal_title：American journal of translational research

authors： Zhang Y,Hong H,Severin GW,Engle JW,Yang Y,Goel S,Nathanson AJ,Liu G,Nickles RJ,Leigh BR,Barnhart TE,Cai W

更新日期：2012-01-01 00:00:00

abstract：:Extinction bursts are characterized by a temporary increase in responding when drug access is withheld from rats trained to self-administer drugs of abuse. Thus far, one study has examined extinction bursts for nicotine self-administration using a 23-h access paradigm [1]. Here we examined extinction bursts using prev...

journal_title：American journal of translational research

authors： Pushparaj A,Pryslawsky Y,Forget B,Yan Y,Le Foll B

更新日期：2012-01-01 00:00:00

abstract：:The histone deacetylase inhibitors, suberoylanilide hydroxamic acid (Vorinostat, Zolinza™) and depsipeptide (Romidepsin, Istodax™) have been approved by the US Food and Drug Administration for the treatment of refractory cutaneous T-cell lymphoma. Numerous histone deacetylase inhibitors are currently undergoing clinic...

journal_title：American journal of translational research

authors： Ververis K,Karagiannis TC

更新日期：2012-01-01 00:00:00

abstract：:The survival kinase Akt and the tumor suppressor LKB1 elicit opposite effects on cell proliferation and tumorigenesis. The present study demonstrates that Akt acts as an upstream kinase of LKB1 to promote the phosphorylation at Ser334 and facilitate its binding to 14-3-3 proteins, resulting in a decreased interaction ...

journal_title：American journal of translational research

authors： Liu L,Siu FM,Che CM,Xu A,Wang Y

更新日期：2012-01-01 00:00:00

abstract：:Although it is well-established that cancer is driven by genetic mutations resulting in the acquisition of onco-genes and the loss of tumor suppressors, until recently many of the genomic details remained obscure. As a result of recent high-throughput DNA sequencing, basic insights into the spectrum of protein coding ...

journal_title：American journal of translational research

authors： Burbelo PD,Ching KH,Bren KE,Iadarola MJ

更新日期：2011-05-15 00:00:00

abstract：:Principal component analysis (PCA) is a data analysis method that can deal with large volumes of data. Owing to the complexity and volume of the data generated by today's advanced technologies in genomics, pro-teomics, and metabolomics, PCA has become predominant in the medical sciences. Despite its popularity, PCA le...

journal_title：American journal of translational research

authors： Nikas JB,Low WC

更新日期：2011-02-01 00:00:00

abstract：:Breast cancer, a worldwide disease with increasing incidence, develops from ductal/lobular epithelium. Nipple aspirate fluid (NAF), secreted from the breast ducts and lobules, can be analyzed to assess metabolic activity in breast microenvironment. Premalignant and malignant cell alterations may produce biochemical si...

journal_title：American journal of translational research

authors： Mannello F,Tonti GA,Simone P,Ligi D,Medda V

更新日期：2010-10-30 00:00:00

abstract：UNLABELLED:3, 3'-diindolylmethane (DIM) modulates estrogen metabolism and acts as an anti-androgen which down-regulates the androgen receptor and prostate specific antigen (PSA). We conducted a dose-escalation, phase I study of BioResponse (BR)-DIM with objectives to determine the maximum tolerated dose (MTD), toxicity...

journal_title：American journal of translational research

authors： Heath EI,Heilbrun LK,Li J,Vaishampayan U,Harper F,Pemberton P,Sarkar FH

更新日期：2010-07-23 00:00:00

abstract：:A surplus of food supply has evoked a worldwide increase in incidence of type 2 diabetes. This trend will have a significant impact on the life span of people living in modern societies. In contrast, reduced calorie intake has significant impact on preventing type 2 diabetes and increasing longevity. Increased product...

journal_title：American journal of translational research

authors： Chang YC,Chuang LM

更新日期：2010-06-10 00:00:00

abstract：:The serine/threonine protein kinase B (PKB, also known as Akt) constitutes an important node in diverse signaling cascades downstream of growth factor receptor tyrosine kinases. Akt plays an essential role in cell survival, growth, migration, proliferation, polarity, and metabolism (lipid and glucose); cell cycle prog...

journal_title：American journal of translational research

authors： Liao Y,Hung MC

更新日期：2010-01-01 00:00:00

abstract：:Activated protein C (APC) is a vitamin-K dependent natural anticoagulant protein. With its function in blood clotting reaction, APC can reduce the risk of venous thrombosis to prevent ischemic disease. A number of in vivo and in vitro studies over the past few decades have revealed that APC also exerted cytoprotective...

journal_title：American journal of translational research

authors： Wang J,Li J

更新日期：2009-07-15 00:00:00

abstract：:Human epithelial mucin, the major glycoprotein component of mucus, plays a critical role in host innate defense response against invading microbes by facilitating the mucociliary clearance. Excess mucin production, however, overwhelms the mucociliary clearance, resulting in not only defective mucosal defense but also ...

journal_title：American journal of translational research

authors： Lim JH,Kim HJ,Komatsu K,Ha U,Huang Y,Jono H,Kweon SM,Lee J,Xu X,Zhang GS,Shen H,Kai H,Zhang W,Xu H,Li JD

更新日期：2009-05-08 00:00:00

abstract：BACKGROUND:Cyclosporin A (CsA) and tacrolimus block T cell activation by inhibiting the phosphatase calcineurin and preventing translocation from the cytoplasm to the nucleus of the transcription factor Nuclear Factor of Activated T cells (NFAT). NFAT compose a family of transcription factors that are turned on during ...

journal_title：American journal of translational research

authors： Al-Daraji WI,Afolayan J,Zelger BG,Abdellaoui A,Zelger B

更新日期：2009-01-22 00:00:00